Primary Citation | Cryo-EM structures of tau filaments from Alzheimer's disease with PET ligand APN-1607. Shi Y, Murzin AG, Falcon B, Epstein A, Machin J, Tempest P, Newell KL, Vidal R, Garringer HJ, Sahara N, Higuchi M, Ghetti B, Jang MK, Scheres SHW, Goedert M Acta Neuropathol (2021) PubMed DOI show all entries for this citation |
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Funding Source | Medical Research Council (MRC, United Kingdom), Japan Agency for Medical Research and Development (AMED), NIH National Institute on Aging (NIH/NIA), Innovative Medicines Initiative, NIH National Institute of Neurological Disorders and Stroke (NIH/NINDS) |
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Status | Deposited | Released | Last Update |
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REL | 2021-03-04 | 2021-03-24 | 2024-07-10 |
Name: Sarkosyl-insoluble fractions from primary age-related tauopathy brainSpecimenType: filament MW: 0.459 MDa pH: 7.5
Component Types | tissue |
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Component Names | Sarkosyl-insoluble fractions from primary age-related tauopathy brain |
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Molecular Types | protein |
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Molecule Names | - Microtubule-associated protein tau
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Sources | Homo sapiens ncbi:9606 |
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Specimen Preparation | vitrification |
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Microscope | FEI TITAN KRIOS (300 kV) |
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Detector | GATAN K2 SUMMIT (4k x 4k) |
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Electron Dose | 58 (e/sq. Å) |
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Number of Particles | 425943 |
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Details: The calibrated pixel size was used during post-processing procedures in RELION.
Map File Size | 144 Mbytes |
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Voxel Dimensions (Å) | 0.82 x 0.82 x 0.82 |
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Map Dimensions (voxels) | 330 x 330 x 330 |
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Map Data Type | IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) |
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Density Statistics | Min -0.053Max 0.106Avg 0Std 0.005 |
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Recommended Contour Level | 0.0212 (4.0 σ) |
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Mol*3DViewer Map Visual Analysis @ EMDBCurrent: files.wwpdb.org (USA)
View EMDB map entry EMD-12549: | |
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View associated model PDB 7nrq: | |
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