Primary Citation | Structure of human TRPV4 in complex with GTPase RhoA. Nadezhdin KD, Talyzina IA, Parthasarathy A, Neuberger A, Zhang DX, Sobolevsky AI Nat Commun (2023) PubMed DOI show all entries for this citation |
---|
Funding Source | German Research Foundation (DFG), NIH National Heart, Lung, and Blood Institute (NIH/NHLBI), NIH National Cancer Institute (NIH/NCI), NIH National Institute of Neurological Disorders and Stroke (NIH/NINDS), NIH National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIH/NIAMS) |
---|
Status | Deposited | Released | Last Update |
---|
REL | 2023-06-02 | 2023-07-05 | 2024-11-06 |
Name: full-length human TRPV4 in complex with agonist 4a-PDDSpecimenType: particle MW: 0.51 MDa pH: 8
Component Types | complex |
---|
Component Names | full-length human TRPV4 in complex with agonist 4a-PDD |
---|
Molecular Types | ligand, protein |
---|
Molecule Names | - (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate
- Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera
|
---|
Sources | Human betaherpesvirus 5 ncbi:10359 Homo sapiens ncbi:9606 |
---|
Ligand IDs: XS9
Specimen Preparation Details: human TRPV4
Specimen Preparation | vitrification |
---|
Vitrification | FEI VITROBOT MARK IV |
---|
Microscope | TFS KRIOS (300 kV) |
---|
Detector | GATAN K3 (6k x 4k) |
---|
Images Collected | 15624 |
---|
Electron Dose | 60 (e/sq. Å) |
---|
Number of Particles | 80823 |
---|
Map File Size | 131 Mbytes |
---|
Voxel Dimensions (Å) | 0.7888 x 0.7888 x 0.7888 |
---|
Map Dimensions (voxels) | 320 x 320 x 320 |
---|
Map Data Type | IMAGE STORED AS FLOATING POINT NUMBER (4 BYTES) |
---|
Density Statistics | Min -0.219Max 0.323Avg 0.001Std 0.01 |
---|
Recommended Contour Level | 0.045 (4.4 σ) |
---|
Mol*3DViewer Map Visual Analysis @ EMDBCurrent: files.wwpdb.org (USA)
View EMDB map entry EMD-40960: | |
---|
View associated model PDB 8t1d: | |
---|