Advanced Topics in EM Structure Determination Workshop

The Workshop on Advanced Topics in EM Structure Determination: Challenging Molecules held Nov 8-13, 2009 at the National Resource for Automated Molecular Microscopy (NRAMM) at the Scripps Research Institute was an intellectually stimulating meeting with over 100 attendees and an outstanding set of instructors. The meeting featured extensive discussion of challenges faced using cryoEM to solve macromolecules that are either small or conformationally variable in structure, including both soluble and membrane proteins, along with extensive discussion of potential solutions through improvements in specimen preparation, imaging, processing and reconstruction. There were also lively discussions regarding the difficult problem of how to properly validate an EM map. Several participants made useful suggestions regarding additional information that could be collected for EMDB entries to help evaluate map quality.

Cathy Lawson presented the poster at right which is an at-a-glance summary of currently available EM deposition and retrieval services and recent improvements implemented by our project team. Click here to download the 8.5" x 11" flyer pdf.